Complete List of Publications
Liu T, Wang H, Kutsovsky DY, Iskols M, Chen H, Ohn CYJ, Patel N, Yang J, SIMON DJ. An axon - T cell feedback loop enhances inflammation and axon degeneration. (2024). Cell Rep. 43(2):113721. PDF.
SIMON DJ#, Belsky DM, Bowen ME, Ohn CYJ, O’Rourke MK, Shen R, Kim G, Pitts J, Attardi LD, Tessier-Lavigne M#. An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53. Dev. Cell. 2021; 56(7):976-984. (# co-corresponding author)
Maor-Nof M, Shipony Z, Lopez-Gonzalez R, Nakayama L, Zhang YJ, Couthouis J, Blum JA, Castruita PA, Linares GR, Ruan K, Ramaswami G, SIMON DJ, Nof A, Santana M, Han K, Sinnott-Armstrong N, Bassik MC, Geschwind DH, Tessier-Lavigne M, Attardi LD, Lloyd TE, Ichida JK, Gao FB, Greenleaf WJ, Yokoyama JS, Petrucelli L, Gitler AD. p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR). Cell. 2021; 184(3):689-708.
Gu Z, Koppel N, Kalamboglas J, Alexandrou G, Li J, Craig C, SIMON DJ, Tessier-Lavigne M, Baccei ML, Martin JH, Yoshida Y. Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway. J Neurosci. 2020; 40(28):5402-5412.
Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, SIMON DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M. Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. 2019; 7;103(3):412-422.e4
Wang G*, SIMON DJ*, Wu Z, Heller E, O’Rourke MK, Hertz NT, Molina H, Zhong G, Tessier-Lavigne M, Zhuang, X. Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration. eLife. 2019; 8:e38730.
SIMON DJ and Watkins TA. Therapeutic opportunities and pitfalls in the treatment of axon degeneration. Curr. Opin. Neurol. 2018; 31(6):693-701.
Sun LO, Mulinyawe SB, Collins HY, Ibrahim A, Li Q, SIMON DJ, Tessier-Lavigne M, Barres BA. Oligodendrocyte Programmed Cell Death through TFEB-PUMA Axis Controls CNS Myelination. Cell. 2018; 13;175(7):1811-26.
Pym E, Sasidharan N, Thompson-Peer KL, SIMON DJ, Anselmo A, Sadreyev R, Hall Q, Nurrish S, Kaplan JM. Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression. eLife. 2017; 6;6.
He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, SIMON DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, Zhuang X. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. PNAS. 2016; 113(21):6029-34.
SIMON DJ*, Pitts J*, Hertz NT, Yang J, Yamagishi Y, Olsen O, Tessic Mark M, Molina H, Tessier-Lavigne M. Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling. Cell. 2016; 164(5):1031-45.
Yang J, Wu Z, Renier N, SIMON DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015; 160(1-2):161-76.
Renier N*, Wu Z*, SIMON DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple method for immunolabeling of large tissue samples for volume imaging. Cell. 2014; 159(4):896-910.
Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, SIMON DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M. Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase. J.Neurosci. 2014; 34(19):6438-47.
SIMON DJ, Weimer RM, McLaughin T, Kallop D, Stanger K, Yang J, O’Leary DDM, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. J.Neurosci. 2012; 32(49):17540-53.
SIMON DJ*, Madison JM*, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008; 133(5):903-15.
Pulver SR, Bucher D, SIMON DJ, Marder E. Constant amplitude of postsynaptic responses for single presynaptic action potentials but not bursting input during growth of an identified neuromuscular junction in the lobster, Homarus americanus. J.Neurobiol. 2005; 62(1):47-61.
Richards KS, SIMON DJ, Pulver SR, Beltz BS, Marder E. Serotonin in the developing stomatogastric system of the lobster, Homarus americanus. J.Neurobiol. 2003; 54(2):380-92.
Gutovitz S, Birmingham JT, Luther JA, SIMON DJ, Marder E. GABA enhances transmission at an excitatory glutamatergic synapse. J.Neurosci. 2001; 21(16):5935-43.
* denotes co-first authorship