mechanisms of neuronal survival

Why do some neurons survive a lifetime while others succumb to neurodegeneration?

Stress-sensing pathways in Neurons

 How does a neuron detect a cellular stress and how can we block this process?

Neuro-immune interactions

 How are neurons protected from inflammatory damage and how do these protections break down in disease?

 

Selected Publications

 

Wang G*, SIMON DJ*, Wu Z, Heller E, O’Rourke MK, Hertz NT, Molina H, Zhong G, Tessier-Lavigne M, Zhuang, X. Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration.  eLife. 2019; 8:e38730.

SIMON DJ and Watkins TA. Therapeutic opportunities and pitfalls in the treatment of axon degeneration. Curr. Opin. Neurol. 2018; 31(6):693-701.

SIMON DJ*, Pitts J*, Hertz NT, Yang J, Yamagishi Y, Olsen O, Tessic Mark M, Molina H, Tessier-Lavigne M. Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling. Cell. 2016; 164(5):1031-45.

Renier N*, Wu Z*, SIMON DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple method for immunolabeling of large tissue samples for volume imaging. Cell. 2014; 159(4):896-910.

SIMON DJ, Weimer RM, McLaughin T, Kallop D, Stanger K, Yang J, O’Leary DDM, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. J.Neurosci2012; 32(49):17540-53.

SIMON DJ*, Madison JM*, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK.  The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008; 133(5):903-15.

Click for complete list of publications 

 

 

 

 

Lab Members

Interested in joining the lab?

We are recruiting graduate students, postdocs, and research technicians interested in molecular neurobiology and neuro-immune interactions. Positions for undergraduate students are also available.

Prospective graduate students can apply via the Weill Cornell Graduate School of Medical Sciences.

Contact David Simon (djs4002@med.cornell.edu)

 

David J. Simon, Ph.D.  Assistant Professor of Biochemistry  djs4002@med.cornell.edu

David J. Simon, Ph.D.

Assistant Professor of Biochemistry

djs4002@med.cornell.edu

 

 

 

Chongzhen Yuan, Ph.D.  Postdoctoral Associate  chy4002@med.cornell.edu

Chongzhen Yuan, Ph.D.

Postdoctoral Associate

chy4002@med.cornell.edu

 
Christine Ohn, B.S.  Research Technician  cho4002@med.cornell.edu

Christine Ohn, B.S.

Research Technician

cho4002@med.cornell.edu