Our website is under construction, but take a look at our interests and key publications



mechanisms of neuronal survival

Why do some neurons survive a lifetime while others succumb to neurodegeneration?

Stress-sensing pathways in Neurons

 How does a neuron detect a cellular stress and how can we block this process?

Neuro-immune interactions

 How are neurons protected from inflammatory damage and how do these protections break down in disease?

Key Publications


SIMON DJ*, Pitts J*, Hertz NT, Yang J, Yamagishi Y, Olsen O, Tessic Mark M, Molina H, Tessier-Lavigne M. Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling. Cell. 2016; 164(5):1031-45.

Renier N*, Wu Z*, SIMON DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple method for immunolabeling of large tissue samples for volume imaging. Cell. 2014; 159(4):896-910.

SIMON DJ, Weimer RM, McLaughin T, Kallop D, Stanger K, Yang J, O’Leary DDM, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. J.Neurosci2012; 32(49):17540-53.






Lab Members

Interested in joining the lab?

The Simon lab will open in Spring 2019. We are recruiting graduate students, postdocs, and research technicians interested in molecular neurobiology and neuro-immune interactions. Positions for undergraduate students are also available.

Prospective graduate students can apply via the Weill Cornell Graduate School of Medical Sciences.

Contact David Simon (djs4002@med.cornell.edu)


David J. Simon  Assistant Professor of Biochemistry  djs4002@med.cornell.edu

David J. Simon

Assistant Professor of Biochemistry